Welcome to the Stocktwits Top 25 Newsletter this week!

The Stocktwits Top 25 reports the 25 best-performing stocks in the S&P 500, Nasdaq 100, and Russell 2000 year to date and tracks their performances over time. To help you understand this data further, check out our FAQ page, and feel free to reach out if you have questions!

Bearish 🐻 | Bullish 🐮 | It’s Complicated 😵‍💫

Here are the Stocktwits Top 25 Lists for this week:

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AI infrastructure, biotech data, and crypto regulation reshuffled this week’s Russell 2000 momentum board.

$ERAS ( ▼ 3.72% ) : Erasca, up 10 spots to #10 and this week’s top dawg: The stock climbed the ranking even after slipping -3.7%, as management kept ERAS-0015’s early response data in view at Morgan Stanley. Risk: The next meaningful clinical update is not expected until H1 2027.

$TWST ( ▲ 7.35% ) : Twist Bioscience, new at #1: Shares gained +7.3% after Twist joined Eli Lilly’s TuneLab as an antibody-data provider for AI drug discovery. Risk: The partnership’s economics were not disclosed, and the stock has already climbed +427% this year.

$MXL ( ▲ 8.17% ) : MaxLinear, up six spots to #4: Shares jumped +8.2% as chip and optical-infrastructure names rallied. The company’s AI networking portfolio gave traders an obvious reason to pile in. Risk: No fresh company-specific catalyst surfaced, leaving this week’s move tied heavily to sector momentum.

$PURR ( ▲ 9.82% ) : Hyperliquid Strategies, new at #11: The crypto treasury stock gained +9.8% as regulators advanced rules for tokenized equities. Sentiment remained bearish at 29% despite 26,400 watchers. Risk: Its equity facility allows discounted share sales, keeping dilution close behind the rally.

$REAX ( ▼ 6.13% ) : Real Brokerage, new at #6: The post-merger real estate play entered the board despite falling -6.1% this week. Traders are still digesting its combination with RE/MAX. Risk: The deal brought a $550M financing commitment into a housing market already squeezed by higher rates.

Next week’s swing factor: Friday’s Sept. 25 durable-goods report will test risk appetite across the board’s high-multiple technology and biotech names.

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